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Development of Standardized Ethanol Extract of Fraxinus Griffithii as CNS Depressant

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Relation http://repository.ubaya.ac.id/227/
http://www.davidpublishing.org
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Title Development of Standardized Ethanol Extract of Fraxinus Griffithii as CNS Depressant
 
Creator Kartini, Kartini
., Sutarjadi
Kirtishanti, AgusIina
Kesuma, Dini
Soediman, Soediatmoko
Hendrajaya, Kusuma
 
Subject RS Pharmacy and materia medica
 
Description Background: Fraxinus griffithii has been widely used as CNS depressant. Its activity based on both empirical and preclinical data. However, standardization on raw material and process of extraction have not been conducted. Methods: Extraction of Fraxinus griffithii was conducted on different part of plants, as well as different solvents and extraction methods. Each extract was standardized both on specific and nonspecific parameters. Additionally, phenobarbital induced sleeping time test was performed on each extract. Results: Leaves of F. griffithii extracted with 70% ethanol by kinetic maceration yielded the highest extract. CNS depressant activity of 70% ethanol extract obtained from F. griffithii leaves by kinetic maceration was the highest compared to the others. Conclusion: All of the extracts have CNS depressant activity, but extract from the leaves, produced by 70% ethanol and kinetic maceration had the optimal activity and quality.
 
Publisher David Publishing Company
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
application/pdf
application/pdf
 
Language en
en
en
 
Identifier /227/3/Kartini_Development%20of%20Standardized_Abstract_2011.pdf
/227/14/Development%20of%20Standardized%20Ethanol%20Extract_2011.pdf
/227/2/Kartini_Development%20of%20Standardized_References_2011.pdf
Kartini, Kartini and ., Sutarjadi and Kirtishanti, AgusIina and Kesuma, Dini and Soediman, Soediatmoko and Hendrajaya, Kusuma (2011) Development of Standardized Ethanol Extract of Fraxinus Griffithii as CNS Depressant. Journal of US-China Medical Science, 8 (10). pp. 617-625. ISSN 1548-6648
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